Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show
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چکیده
منابع مشابه
Mitochondrial quality control beyond PINK1/Parkin
Neurons strictly rely on proper mitochondrial function and turnover. They possess a high energy requirement which is mostly fueled by mitochondrial oxidative phosphorylation. Moreover the unique morphology of neurons implies that mitochondria need to be transported along the axons to sites of high energy demand. Finally, due to the non-dividing state of neurons, cellular mitosis cannot dilute d...
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The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria, which induces mitophagy generating polyUb chain. However, Parkin Ser65 phosphorylation is insufficient for Parkin mitochondrial translocation. H...
متن کاملThe PINK1/Parkin pathway: a mitochondrial quality control system?
Significant insight into the mechanisms that contribute to dopaminergic neurodegeneration in Parkinson disease has been gained from the analysis of genes linked to rare heritable forms of parkinsonism such as PINK1 and parkin, loss-of-function mutations of which cause autosomal recessive parkinsonism. PINK1 encodes a mitochondrially targeted Ser/Thr kinase and parkin encodes a ubiquitin-protein...
متن کاملPink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease.
Mutations in PARKIN, PTEN-induced kinase 1 (PINK1) and DJ-1 are found in autosomal recessive forms and some sporadic cases of Parkinson's disease. Recent work on these genes underscores the central importance of mitochondrial dysfunction and oxidative stress in Parkinson's disease. In particular, pink1 and parkin loss-of-function mutants in Drosophila show similar phenotypes, and pink1 acts ups...
متن کاملDrosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy; however, its precise role in pathogenesis is unclear. Recent evidence suggests that Parkin is recruited to damaged mitochondria, possibly aff...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2016
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2016.104